内网

检测到您当前使用浏览器版本过于老旧,会导致无法正常浏览网站;请您使用电脑里的其他浏览器如:360、QQ、搜狗浏览器的极速模式浏览,或者使用谷歌、火狐等浏览器。

下载Firefox

Modeling human brain development and developmental diseases using hiPSCs

日期: 2018-11-28
js3845金沙线路2018年度秋季学期学术系列讲座之十二
题目:Modeling human brain development and developmental diseases using hiPSCs
讲座人:Guo-li Ming, PhD
Perelman Professor of Neuroscience
University of Pennsylvania
时间:2018年12月21日(星期五),13:00-14:30
地点:js3845金沙线路邓祐才报告厅 
主持人:宋艳研究员&徐成冉研究员
摘要:
Human Induced pluripotent stem cells (hiPSCs) has the potential to generate all cell types of a human body under 2D culture conditions or form organ like structures- organoids, under 3D culture conditions. Cerebral organoid cultures from human iPSCs have been recently developed to recapitulate the cytoarchitecture of the developing brain. These hiPSC based model systems offer unique advantages in understanding molecular and cellular mechanisms governing embryonic neural development and in modeling neurodevelopmental disorders, such as brain malformation and neuropsychiatric disorders. We have improved the organoid technology and developed a protocol to produce forebrain-specific organoids derived from hiPSCs using a novel miniaturized spinning bioreactor that recapitulate the human embryonic cortical development. I will discuss our recent work using these systems to understand ZIKV induced microcephaly and mental disorders.
欢迎各位老师同学积极参加!