js3845金沙线路2017年度秋季学期学术系列讲座之十三
题目：Targeting Ubiquitin Ligases: Hormones, Metabolites, and New Therapeutic Drugs
讲座人：Ning Zheng, Ph.D
Professor
Howard Hughes Medical Institute
Department of Pharmacology
University of Washington
时间：2017年12月15日（星期五），13:00-14:30
地点：js3845金沙线路邓祐才报告厅 
主持人：高宁
摘要：
Ubiquitination is a widespread form of protein post-translational modification, which regulates diverse biological pathways in eukaryote cells. Ubiquitin ligases catalyze the final step of ubiquitin conjugation to specific substrates and are widely considered as the next generation therapeutic targets.  Extensive efforts in discovering ubiquitin ligase inhibitors, however, failed in both academia and industry over the past two decades. This presentation will focus on how advances in plant biology have taught us an important lesson in the "pharmacology" of protein ubiquitination, which pointed to a completely unexpected direction in developing drugs harnessing the power of ubiquitin ligases.
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